imported>Gydbwiki at 18:07, 10 November 2009

2009-11-10T18:07:29Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=8500 X04132]
|type=412/Mdg1
|genus=Undetermined
|subfamily=Branch 2
|family=Ty3/Gypsy
|group=LTR retroelements
|description=
412 is a LTR retrotransposon described in ''Drosophilamelanogaster'' ([[Literature:85444|Poter et al. 1979]]; [[Literature:85336|Yuki et al. 1986a]]). In embryos of the ''Drosophila'' strain Df(3L)AC1 the expression of 412 is regulated by the homeotic genes abdominal-A and abdominal-B. This element provides thus a useful early marker for the development of the gonadal mesoderm in ''Drosophila'' embryos ([[Literature:9053|Brookman et al. 1992]]). 412 is similar to ''mdg1 ''and belongs to ''412/mdg1 '' clade [[Literature:46552|(Malik and Eickbush1999]]). Phylogenetic analyses suggest that this clade is closely related to errantiviruses. The integrase product encoded by'' 412/mdg1'' elements has been related to a single copy gene, which codifies for a putative integrase protein ([[GIN-1]]) in humans and other vertebrates ([[Literature:44593|Lloréns and Marín 2001]]). The genomic structure of 412 is 6.9 Kb in size including LTRs of 310 nt. The internal region of this element displays a Primer Binding Site (PBS) complementary to a tRNA <sup>Lys</sup>, three Open Reading Frames (ORFs) coding for a gag precursor, another ORF for a pol precursor, and a Polypurine Tract (PPT) adjacent to the 3′LTR ([[Literature:85335|Yuki et al. 1986b]]).

|structure=412.png
|host=Drosophila melanogaster
|hostpic=Drosophila_melanogaster.gif
|literature=*[[Literature:15303|Mobile DNA II. (Craig et al. 2002)]]
|picowner=[http://www.molgen.mpg.de/ Image, courtesy of Andreas Trepte, Max-Planck Institute for Molecular Genetics]
}}

Element:412 - Revision history

imported>Gydbwiki at 18:07, 10 November 2009