imported>Gydbwiki at 08:04, 4 May 2010

2010-05-04T08:04:59Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=76786461 76786461]
|type=
Undetermined
|genus=
Epsilonretrovirus
|subfamily=
Class 1
|family=
Retroviridae
|group=
LTR retroelements
|description=''Atlantic salmon swim bladder sarcoma virus'' (ASSBSV) is an epsilonretrovirus originally isolated from ''Salmo salar'' species. ASSBSV belongs to genus ''Epsilonretrovirus'' within ''Retroviridae'' family (''International Committee on the Taxonomy of Viruses'' -ICTV- [[Literature:100589|Fauquet ''et al''. 2005]]) and according to [[Literature:100596|Llorens ''et al''. 2009]] is located within Class 1 of the [[Retroviridae|''Retroviridae'']] family. This retrovirus-infected salmons usually are in poor physical condition and display swollen abdomens that upon necropsy were found to contain multinodular masses of neoplastic cells occupying external and internal surfaces of the swim bladder. These tumors, histologically classified as leiomyosarcomas or fibrosarcomas ([[Literature:100731|McKnight 1978]]), cause an approximately a 35% of population mortality ([[Literature:58208|Paul ''et al.'' 2006]]).

The genomic structure of ASSBSV is 10.9 Kb in length, including LTRs of 713 pb of sequence at each end of the proviral genome ([[Literature:58208|Paul ''et al.'' 2006]]). The internal region of this retrovirus displays a Primer Binding Site (PBS), three Open Reading Frames (ORFs) for ''gag'', ''pol'' (PR, RT, RNaseH, INT) and ''env'' genes characteristic of retroviruses, as well as a Polypurine Tract (PPT) adjacent to the 3´LTR ([[Literature:58208|Paul ''et al.'' 2006]]).
|structure=ASSBSV_final.png
|host=Salmo salar
|hostpic=AtlanticSalmon.jpg
|literature=*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.fws.gov/newengland/outreachnhenvirothon_fish.htm Courtesy of Duane Raver/USFWS]
}}
[[Category:Element]]

Element:ASSBSV - Revision history

imported>Gydbwiki at 08:04, 4 May 2010