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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=9629644 9629644]
|type=Undetermined
|genus=Spumaretrovirus
|subfamily=Class 3
|family=Retroviridae
|group=LTR retroelements
|description= ''Bovine foamy virus'' (BFV) is a foamy retrovirus originally isolated
from bovine species. BFV belongs to genus ''Spumaretrovirus'' within
''Retroviridae'' family (''International Committee on the Taxonomy of Viruses''
-ICTV- [[Literature:100589|Fauquet ''et al.'' 2005]]) and according to
[[Literature:100596|Llorens ''et al''. (2009)]] is located within Class 3 of the
[[Retroviridae|''Retroviridae'']] family. The foamy viruses family causes a pronounced
cytopathic effect in a wide variety of tissue culture cells, but BFV
appears to be benign ''in vivo''. This lack of apparent pathogenicity has led to the
idea that the foamy viruses may be suitable delivery vectors for gene therapy
([[Literature:65234|Russell and Miller 1996]]; [[Literature:67249|Schmidt and
Rethwilm 1995]]). However, it has been suggested that BFV presence in the host may
contribute to diseases caused by other pathogens ([[Literature:100710|Marino ''et
al.'' 1995]]).

The genomic structure of BFV is 12.2 Kb in size including LTRs of 1.305 Kb
([[Literature:31843|Holzschu ''et al.'' 1998]]). The internal region of this
retrovirus displays a Primer Binding Site (PBS) complementary to a
tRNA<sup>Lys</sup>, three Open Reading Frames (ORFs) for ''gag'', ''pol'' and
''env'' genes characteristic of retroviruses, the 3´accessory Bel-1 (BF-ORF1)
and Bel-2 (BF-ORF2) genes ([[Literature:100712|Renshaw and Casey 1993]]), and a
Polypurine Tract (PPT) adjacent to the 3´LTR ([[Literature:31843|Holzschu ''et al.''
1998]]). BFV ''gag'' and ''pol'' ORFs overlap, and contain the features characteristic of retroviruses (gag, protease, reverse transcriptase, RNase H and integrase) ([[Literature:31843|Holzschu ''et al''. 1998]]). The ''env'' gene encodes a protein that is over 40% identical in sequence to that of ''Human foamy virus'' (HFV). Two accessory genes, ''Bel-1'' and ''Bel-2'', are located downstream to ''env''. The first one includes a short overlap between ''env'' gene while Bel-2 overlaps with the first accessory ORF and the 3´LTR region terminal ([[Literature:31843|Holzschu ''et al.'' 1998]]).
|structure=BFV.png
|host=Bovidae sp.
|hostpic=Bovidae_sp.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Carlos Llorens, <br>Copyright, GyDB, Biotech Vana]
}}
[[Category:Element]]

Element:BFV - Revision history

imported>Gydbwiki at 09:07, 4 May 2010