imported>Gydbwiki at 15:29, 3 May 2010

2010-05-03T15:29:40Z

New page

{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=2801494 AF033818]
|type=
Oncovirinae C-type
|genus=
Deltaretrovirus
|subfamily=
Class 2
|family=
Retroviridae
|group=
LTR retroelements
|description= ''Bovine Leukemia Virus'' (BLV) is a complex retrovirus associated with Enzootic Bovine Leukosis (EBL), the most common neoplastic cattle disease. Infection by this virus can be clinically silent, but detection and synthesis of BLV virus particles has been observed in infected lymphocyte cultures ([[Literature:85406|Stock and Ferrer 1972]]; [[Literature:3729|Baliga and Ferrer 1977]]; [[Literature:85405|Ferrer, Avila, and Stock 1977]]; [[Literature:85483|Ferrer, Cabradilla and Gupta 1980]]; [[Literature:21948|Ferrer 1980]]; [[Literature:37483|Kettmann ''et al.'' 1980]]; [[Literature:85503|Burny ''et al.'' 1985]]; [[Literature:75300|Tajima ''et al.'' 1998]]). Together with other leukemia retroviruses, BLV belongs to the genus ''Deltaretrovirus'' ([[Literature:65613|Sagata ''et al.'' 1985]]; [[Literature:75300|Tajima ''et al.'' 1998]]; [[Literature:100589|Fauquet ''et al''. 2005]]). The genomic structure of BLV is 8.4-8.5 Kb in size including LTRs of 763 nt (pro-5´LTR and pro3´LTR of 321 and 442 nt respectively). The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Pro</sup>; three Open Reading Frames (ORFs) for ''gag'', ''pol'', and ''env'' genes characteristic of retroviruses, and accessory genes ''rex'' and ''tax'', both essential for viral replication and cellular transformation in infected cells (see [[Element:HTLV-1|HTLV-1]] or [[Accessory_Genes|accessory genes]]), and finally, a Polypurine Tract (PPT) adjacent to 3´LTR ([[Literature:65613|Sagata ''et al.'' 1985]]).
|structure=Blv.png
|host=Bovidae sp.
|hostpic=Bovidae_sp.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Carlos Llorens, <br>Copyright, GyDB, Biotech Vana]
}}

Element:BLV - Revision history

imported>Gydbwiki at 15:29, 3 May 2010