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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=9634977 9634977]
|type=
Undetermined
|genus=
Spumaretrovirus
|subfamily=
Class 3
|family=
Retroviridae
|group=LTR retroelements
|description=''Equine foamy virus'' (EFV) is a foamy retrovirus originally
isolated from equine species. EFV belongs to genus ''Spumaretrovirus'' within
''Retroviridae'' family (''International Committee on the Taxonomy of Viruses''
-ICTV- [[Literature:100589|Fauquet ''et al''. 2005]]) and according to
[[Literature:100596|Llorens ''et al''. (2009)]] is located within Class 3 of the
[[Retroviridae|''Retroviridae'']] family. Similar to other foamy virus, EFV
exhibits a highly characteristic ultrastructure and induces syncytium formation and
subsequent cell lysis on a large number of cell lines
([[Literature:100722|Tobaly-Tapiero ''et al.'' 2000]]).

The genomic structure of EFV is 12.035 Kb in size including LTRs of 1.449 bp
([[Literature:100722|Tobaly-Tapiero ''et al.'' 2000]]). The internal region of this
retrovirus displays a Primer Binding Site (PBS) complementary to a
tRNA<sup>Lys</sup>, three Open Reading Frames (ORFs) for ''gag'', ''pol'' and
''env'' genes characteristic of retroviruses, two 3´accessory genes, and a
Polypurine Tract (PPT) adjacent to the 3´LTR
([[Literature:100722|Tobaly-Tapiero ''et al.'' 2000]]). The predicted Gag protein of
EFV consists of 559 amino acids; the ORF of the ''pol'' gene -which harbors the
protease, RT, RNase H and integrase domains- begins at position 3157 and consists of
1154 residues. The ''env'' gene encodes a predicted 987-residue and downstream to
this ORF are located the two accessory genes, ''Tas-1'' (ORF 1) and ''Bel-2''
([[Literature:100722|Tobaly-Tapiero ''et al.'' 2000]]). The first one, the Tas-1 ORF
(the spumaretroviruses transactivator, also called Bel 1) transactivates viral
gene expression by direct binding to the viral DNA on specific sequences in the long
terminal repeat (LTR) and in an internal promoter (IP)
([[Literature:100722|Tobaly-Tapiero ''et al.'' 2000]]; [[Literature:42329|Lecellier
''et al.'' 2002]]).
|structure=EFV.png
|host=Equidae sp.
|hostpic=Equidae_sp.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
*[[Literature:15303|Mobile DNA II. (Craig ''et al.'' 2002)]]
|picowner=[http://www.biotechvana.com Image, Daniela Bezemer, <br>Copyright, GyDB, Biotech Vana]
}}
[[Category:Element]]

Element:EFV - Revision history

imported>Gydbwiki at 09:04, 4 May 2010