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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=20143424 20143424]
|type=
|genus=Caulimovirus
|subfamily=Class 1
|family=Caulimoviridae
|group=LTR retroelements
|description=''Figwort mosaic virus '' (FMV) is a plant pararetrovirus belonging to the genus ''Caulimovirus'' of ''Caulimoviridae'' family (''International Committee on the Taxonomy of Viruses'' -ICTV- [[Literature:100589|Fauquet ''et al''. 2005]]). Although its original host was the flowering plant ''Scrophularia californica'' (''Scrophulariaceae'' family), it is also able to infect solanaceous plants ([[Literature:100732|Rollo ''et al.'' 1986]]; [[Literature:100733|Richins ''et al.'' 1987]]).

FMV isometric virions are composed of a genomic circular double-stranded DNA of 7743 bp containing four discontinuities, one in the (-) strand and three in the complementary strand. The genome is organized into seven major open reading frames (ORFs) whose size and organization are similar to those of known caulimoviruses ([[Literature:100733|Richins ''et al.'' 1987]]). ORF I encodes a protein of 327 amino acids (aa) associated to cell-to-cell movement (MOV); the ORF II (164 aa) and ORF III (115 aa) predicted products showing sequence similarities with the "aphid transmission factor" (ATF) and "virion associated protein" (VAP), respectively. ORF IV encodes the putative COAT protein and contains the "RNA-binding" motif characteristic of the ''Caulimoviridae'' ''Gag''-like domain (C-X-C-X2-C-X4-H-X4-C ) ([[Literature:8054|Bouhida ''et al.'' 1993]]; [[Literature:100605|Hull 1996]]; [[Literature:100596|Llorens ''et al'' 2009]]). ORF V product is a polyprotein of 666 aa displaying the typical ''Pol'' domains -aspartic protease (PR), reverse transcriptase (RT) and RNase H (RH)- while the ORF VI-encoded product of 512 aa is similar to the caulimoviruses-related "Translational transactivator proteins" (TAVs). The small ORF VII immediately precedes ORF I and encodes a 7.4 kDa protein which function is still unknown ([[Literature:100733|Richins ''et al.'' 1987]]). Like other ''Caulimovirus'' species (CERV, CaMV, EVCV, LLDAV), two intergenic regions are also present in the genome of FMV: a large intergenic region (LIR) located between ORFs VI (TAV) and VII, and a small intergenic region (SIR) located between ORFs V (Pol) and VI. These regions contain two transcriptional promoter sequences that transcribe whole genome of the virus (that within the LIR) or only the ORF VI (that within the SIR) ([[Literature:100734|Sanger ''et al.'' 1990]]; [[Literature:100730|Bhattacharyya ''et al.'' 2002]]).
|structure=FMV.png
|host=Scrophularia californica
|hostpic=Scrophularia_californica.jpg
|literature=
|picowner=[http://en.wikipedia.org/wiki/File:Scrophulariacalifornica.jpg Courtesy of Wikipedia, copyright of the authors Gordon Leppig & Andrea J. Pickart]
}}
[[Category:Element]]

Element:FMV - Revision history

imported>Gydbwiki at 14:12, 17 March 2010