imported>Ldominguez at 07:50, 4 May 2010

2010-05-04T07:50:26Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=9630707 NC_001940]
|type=
Undetermined
|genus=
Gammaretrovirus
|subfamily=
Class 1
|family=
Retroviridae
|group=
LTR retroelements
|description=
''Feline Leukemia Virus'' (FeLV) is a retrovirus characterized in the domestic cat and originally isolated in 1964. The following subgroups have been detected from a sequence variation in the viral surface env-like Surface glycoprotein ([[Literature:12405|Chen ''et al.'' 1998 and references therein]]):

#FeLV-A is an ecotropic virus present in all natural isolates.
#FeLV-B is a polytropic virus concurrent with FeLV-A, which is over-represented in the lymphosarcomas of infected but otherwise healthy cats.
#FeLV-C is also polytropic, although more infrequent and related to FeLV-A or FeLV-A/plus/FeLV-B. It is known that this variant induces aplasmatic anemia in cats, and it has been speculated that this subgroup might be a variant of FeLV-A.

The "FeLV-A Rickard" strain is taken as a representative. Its genomic structure is 8.4 Kb size including LTRs of 0.5 Kb. The internal region displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Pro</sup>, a single Open Reading Frame (ORF) encoding the gag-pol polyproteins, an ORF for the env, and also a Polypurine Tract (PPT) adjacent to the 3′LTR ([[Literature:12405|Chen ''et al.'' 1998]]).
|structure=Felv.png
|host=Felis catus
|hostpic=Felis_catus.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Carlos Llorens, <br>Copyright, GyDB, Biotech Vana]
}}

Element:FeLV - Revision history

imported>Ldominguez at 07:50, 4 May 2010