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2010-05-03T14:35:33Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=157583 M12927]
|type=Gypsy
|genus= Errantiviridae
|subfamily=Branch 2
|family=Ty3/Gypsy
|group=LTR retroelements
|description=''Gypsy'' is a fly-retrovirus originally described as a fragment of DNA cloned from several stocks of ''D. melanogaster'', carrying suppressible mutations in the bithorax complex ([[Literature:51052|Modolell, Bender, and Messelson 1983]]). ''Gypsy ''was the first retrovirus reported whose infectious properties were empirically tested in insects ([[Literature:71127|Song ''et al.'' 1994]]; [[Literature:85378|Kim ''et al.'' 1994]]) and has been also involved in occasional horizontal transfer events among other ''Drosophila'' species ([[Literature:50696|Mizrokhi and Mazo 1991]]; [[Literature:908|Alberola and de Frutos 1996]]; [[Literature:76463|Terzian ''et al.'' 2000)]]. '' Gypsy'' belongs to the genus ''Errantiviridae'' ([[Literature:7342|Boeke ''et al.'' 1999]]; [[Literature:85379|Pringle 1998]]; [[Literature:61062|1999]];[[Literature:32800| Hull 1999]]), a lineage of fly-retroviruses and LTR retrotransposons phylogenetically related to ''412/mdg1'' clade [[Literature:78091|(Tubio, Naveira and Costas 2005]]). The genomic structure of ''Gypsy'' is 7.4 Kb in size including LTRs of 482 nt. The internal region displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Lys</sup>, three Open Reading Frames (ORFs) for ''gag'', ''pol'', and ''env'' genes, and a Polypurine Tract (PPT) adjacent to the 3´LTR ([[Literature:47371|Marlor, Parkhurst y Corces 1986]]). ''Gypsy'' also displays an insulator element (gypsy insulator) of 350 nt at an untranslated zone of the transcribed 5´region ([[Literature:70766|Smith and Corces 1992]]; [[Literature:24939|Gdula, Gerasimova and Corces 1996]]; [[Literature:24938|Gdula and Corces 1997]]). Insulators may normally function to compartmentalize the genome into independent domains of gene expression. Insulators can block activation of transcription when located between the enhancer and the promoter, and can shield transgenes from position effects caused by surrounding chromatin ([[Literature:85459|Capelson and Corces 2004]]; [[Literature:85460|Felsenfeld ''et al.'' 2004]]). The expression of ''Gypsy'' is repressed by a host gene named flamenco ([[Literature:9438|Bucheton 1995]] and references therein).
|structure=Gypsy.png
|host=Drosophila melanogaster
|hostpic=Drosophila_melanogaster.gif
|literature=*[[Literature:15303|Mobile DNA II. (Craig et al. 2002)]]
|picowner=[http://www.molgen.mpg.de/ Image, courtesy of Andreas Trepte, Max-Planck Institute for Molecular Genetics]
}}

Element:Gypsy - Revision history

imported>Gydbwiki at 14:35, 3 May 2010