imported>Sukanya at 15:30, 6 May 2011

2011-05-06T15:30:00Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=182152 M14123]
|type=
Undetermined
|genus=
Betaretrovirus
|subfamily=
Class 2
|family=
Retroviridae
|group=
LTR retroelements
|description= ''Human Endogenous Retrovirus K10'' (HERV-K10) is a C-type betaretrovirus originally described as the sequence homologous to Syrian hamster intracisternal retroviral A-particles ([[Literature:56420|Ono ''et al.'' 1986]]). This retrovirus belongs to the genus ''Betaretrovirus'', which comprises both B- and D-type primate retroviruses. Interestingly, D-type betaretroviruses present a common surface receptor also used by the baboon and cat endogenous C-type gammaretroviruses (BaEVM, RD114), cellular infection by any of them can interfere with other D-type members, and also with BaEVM and RD114 ([[Literature:12209|Chatterjee and Hunter 1980]]; [[Literature:71083|Sommerfelt and Weiss 1990]]). This evidence seems to be related with the high similarity displayed between env polyproteins encoded by gammaretroviruses and D-type betaretroviruses, indicating that betaretroviruses and gammaretroviruses may have been involved in an ancient recombinatorial event ([[Literature:71146|Sonigo ''et al.'' 1986]]; [[Literature:100589|Fauquet ''et al''. 2005]]) or that they share a common ancestor ([[Phylogeny:ENV_Retroviridae|see env tree in section "phylogenies"]]).

The genomic structure of HERV-K10 is 9.2 Kb in size including LTRs of 1Kb. The internal region displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Lys</sup>, Open Reading Frames (ORFs) for ''gag'', ''dut/pr'', and ''pol/env'' genes, and a Polypurine Tract (PPT) adjacent to the 3´LTR ([[Literature:56420|Ono ''et al.'' 1986]]; [[Literature:20174|Elder ''et al.'' 1992]]; [[Literature:58348|Payne and Elder 2001]]). We also have found that HERV-K10 presents a putative accessory gene ''Orf-x'' that is common among many other betaretroviruses, and that was originally described in JSRV betaretroviruses ([[Literature:3496|Bai ''et al.'' 1999]]; [[Literature:64403|Rosati ''et al.'' 2000]]).

|structure=Herv-e.png
|host=Homo sapiens
|hostpic=Homo_sapiens.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Carlos Llorens, <br>Copyright, GyDB, Biotech Vana]
}}

Element:HERV-K10 - Revision history

imported>Sukanya at 15:30, 6 May 2011