imported>Sukanya at 15:31, 6 May 2011

2011-05-06T15:31:32Z

New page

{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=9629127 Y07725]
|type=
Undetermined
|genus=
Spumaretrovirus
|subfamily=
Class 3
|family=
Retroviridae
|group=
LTR retroelements
|description=''Human Foamy Virus'' (HFV) is a foamy retrovirus originally isolated from a nasopharyngeal carcinoma patient ([[Literature:276|Achong ''et al.'' 1971]]). Within the ''Retroviridae'' family, HFV belongs to the genus ''Spumaretrovirus'' (for a review see [[Literature:49494|Meiering and Linial 2001]]). HFV has been isolated from patients with various diseases such as toxic encephalopathy ([[Literature:85412|Cameron, Mirchall and Moses 1978]]), chronic myeloid leukemia ([[Literature:85148|Young, Samuels and Clarke 1973]]), thyroiditis ([[Literature:85413|Stancek ''et al.'' 1975]]; [[Literature:82387|Werner and Gelderblom 1979]]; [[Literature:85414|Wick ''et al.'' 1992]]) and Grave's disease ([[Literature:13458|Ciampolillo ''et al.'' 1989]]). The pathology of HFV is however, not well known.

The genomic structure of HFV is 13.2 Kb in size including LTRs of 1.8Kb. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Lys1-2</sup>, Open Reading Frames (ORFs) for ''gag'', ''pol'' and ''env'' genes characteristic of retroviruses, accessory ''bel1'' and ''bel2'' genes, and a Polypurine Tract (PPT) adjacent to the 3´LTR ([[Literature:85497|Flügel 1991]]; [[Literature:39049|Kogel, Aboud and Flügel 1995]]). As described by [[Literature:52900|Muranyi and Flügel]] (1991) in human ''Spumaretrovirus'', a chimeric protein termed Bet (or ''bel3'') has also been observed in HFV; it derives from splicing of the N-terminal amino acids of ''bel1'' in frame with the bulk of the ''bel2''.
|structure=Hfv.png
|host=Homo sapiens
|hostpic=Homo_sapiens.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Carlos Llorens, <br>Copyright, GyDB, Biotech Vana]
}}

Element:HFV - Revision history

imported>Sukanya at 15:31, 6 May 2011