imported>Gydbwiki at 15:18, 3 May 2010

2010-05-03T15:18:34Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=331338 M80216]
|type=
Undetermined
|genus=
Betaretrovirus
|subfamily=
Class 2
|family=
Retroviridae
|group=
LTR retroelements
|description= ''Jaagsiekte Sheep Retrovirus'' (JSRV) is a retrovirus originally reported in sheep and cattle, and is the causal agent of infectious pulmonary adenomatosis ([[Literature:85494|Dungal, Gislason, and Taylor 1938]]; [[Literature:85429|Coetzee, Els and Verwoerd 1976]]; [[Literature:80050|Verwoerd ''et al.'' 1983]]; [[Literature:17603|Demartini ''et al.'' 1987]]; [[Literature:78273|Tustin ''et al.'' 1988]]; [[Literature:84974|York ''et al.'' 1991]]; [[Literature:84973|1992]]). JSRV has also been reported in the mononuclear phagocytes and lymphocytes C and T of sheep ([[Literature:85495|Holland ''et al.'' 1999]]). The genetic organization of this retrovirus is characteristic of type-B oncoviruses ([[Literature:84973|York ''et al.'' 1992]]). Thus, this retrovirus belongs to the genus ''Betaretrovirus'', which comprises both B- and D-type retroviruses. Interestingly, D-type betaretroviruses present a common surface receptor also used by the baboon and cat endogenous C-type gammaretroviruses (BaEVM, RD114), cellular infection by any of them can interfere with other D-type members, and also with BaEVM and RD114 ([[Literature:12209|Chatterjee and Hunter 1980]]; [[Literature:71083|Sommerfelt and Weiss 1990 ]]). This evidence seems to be related with the high similarity displayed between env polyproteins encoded by gammaretroviruses and D-type betaretroviruses, indicating that betaretroviruses and gammaretroviruses may have been involved in an ancient recombinatorial event ([[Literature:71146|Sonigo et al 1986]]; [[Literature:100589|Fauquet ''et al''. 2005]]) or that they share a common ancestor ([[Phylogeny:ENV_Retroviridae|see env tree in section "phylogenies"]]).

The genomic structure of JSRV is 7.5 Kb in size including pro-5´LTR of 126 nt and pro-3´LTR of 277 nt. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Lys1,2</sup>, five Open Reading Frames (ORFs) for ''gag'', ''dut/pro'', ''pol'', ''Orf-x'', and ''env'' genes, and a Polypurine Tract (PPT) adjacent to the 3´ LTR ([[Literature:84974|York ''et al.'' 1991]]; [[Literature:84973|1992]]; [[Literature:3496|Bai ''et al.'' 1999]]; [[Literature:20174|Elder ''et al.'' 1992]]; [[Literature:58348|Payne and Elder 2001]]).
|structure=Jsrv.png
|host=Ovis sp.
|hostpic=Ovis_sp.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Enrique Donat, <br>Copyright, GyDB, Biotech Vana]
}}

Element:JSRV - Revision history

imported>Gydbwiki at 15:18, 3 May 2010