https://gydb.org/index.php?action=history&feed=atom&title=Element%3AK-HERV 2026-06-09T18:15:37Z Revision history for this page on the wiki MediaWiki 1.35.0 https://gydb.org/index.php?title=Element:K-HERV&diff=581&oldid=prev 2011-05-06T16:34:16Z

<p></p> <p><b>New page</b></p><div>{{Element<br /> |genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&amp;val=73697544 DQ112152]<br /> |type= Undetermined<br /> |genus=Betaretrovirus<br /> |subfamily=Class 2<br /> |family=Retroviridae<br /> |group=LTR retroelements<br /> |description=A variety of distinct HERV families have been identified in the human genome, which are remnants of exogenous retroviruses that entered the germ line millions of years ago ([[Literature:42059|Lavie ''et al.'' 2004]]), thus in the human genome was recently estimated to contain 30 to 50 distinct HERV families ([[Literature:25672|Gifford and Tristem 2003]]).<br /> In particular, the human endogenous retrovirus K50D (K-HERV) is an element originally isolated from human species ([[Literature:42059|Lavie ''et al.'' 2004]]) and counterpart of HERV-K10. These two belong to genus ''Betaretrovirus'' within ''Retroviridae'' family (''International Committee on the Taxonomy of Viruses'' -ICTV- [[Literature:100589|Fauquet ''et al''. 2005]]) and according to [[Literature:100596|Llorens ''et al''. 2009]] is located within Class 2 of the [[Retroviridae|''Retroviridae'']] family. <br /> <br /> The genome ov K-HERV is 9.4 Kb in size including LTRs of approximately 960 bp that flank an internal coding region ([[Literature:42059|Lavie ''et al''. 2004]]). According to ([[Literature:42059|Lavie ''et al.'' 2004]]), the internal region of this retrovirus contains the typical Primer Binding Site (PBS) and polypurine Tract (PPT) characteristic of retroviruses and five Open Reading Frames (ORFs): one coding for gag, second for a protein product containing the dUTP/PR domains typical of betaretroviruses, third codes for a pol polyprotein including the RT-RNaseH-INT domains, fourth codes for env, and fifth for the ORFX that overlaps pol (as typically observed in betaretroviruses). As observed in other betaretroviruses, ORFX shows multiple stops codons but present a high degree of conservation. <br /> |structure=K-HERV.png<br /> |host=Homo sapiens<br /> |hostpic=Homo_sapiens.gif<br /> |literature=<br /> *[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]<br /> |picowner=[http://www.biotechvana.com Image, Carlos Llorens, &lt;br&gt;Copyright, GyDB, Biotech Vana]<br /> }}<br /> [[Category:Element]]</div>

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