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2010-05-03T15:16:21Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=9627210 NC_001550]
|type=
Undetermined
|genus=
Betaretrovirus
|subfamily=
Class 2
|family=
Retroviridae
|group=
LTR retroelements
|description= ''Mason-Pfizer Monkey Virus'' (MPMV) is a D-type retrovirus originally described from a mammary tumor in a rhesus monkey female ([[Literature:85430|Chopra and Mason 1970]]). This retrovirus belongs to the genus ''Betaretrovirus'', which comprises both B- and D-type retroviruses. Interestingly, D-type betaretroviruses present a common surface receptor also used by the baboon and cat endogenous C-type gammaretroviruses (BaEVM, RD114), cellular infection by any of them can interfere with other D-type members, and also with BaEVM and RD114 ([[Literature:12209|Chatterjee and Hunter 1980]]; [[Literature:71083|Sommerfelt and Weiss 1990 ]]). This evidence seems to be related with the high similarity displayed between env polyproteins encoded by gammaretroviruses and D-type betaretroviruses, indicating that betaretroviruses and gammaretroviruses may have been involved in an ancient recombinatorial event ([[Literature:71146|Sonigo et al 1986]]; [[Literature:100589|Fauquet ''et al''. 2005]]) or that they share a common ancestor ([[Phylogeny:ENV_Retroviridae|see env tree in section "phylogenies"]]).

The genomic structure of MPMV is 8.5 Kb size, including pro-5´LTR-"R/U5 and pro-3´LTR-U3/R of 140-700 and 973 nt, respectively. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Lys</sup>, Open Reading Frames (ORFs) for ''gag'', ''dut/pro'', ''pol'', and ''env'' genes, a Polypurine Tract (PPT), adjacent to the 3´LTR ([[Literature:71146|Sonigo ''et al.'' 1986]]; [[Literature:85478|Petropoulos 1997]]; [[Literature:20174|Elder ''et al.'' 1992]]; [[Literature:58348|Payne and Elder 2001]]). We have also found that MPMV also presents a putative accessory gene '''Orf-x''' that is common among many other betaretroviruses, and that was originally described in JSRV betaretroviruses ([[Literature:3496|Bai ''et al.'' 1999]]; [[Literature:64403|Rosati ''et al.'' 2000]]). Also, a three-copy tandem of an ORF similar to the accessory gene '''Sorf''' displayed in each LTR of the SRV-1 retrovirus.

|structure=Mpmv.png
|host=Macaca mulatta
|hostpic=Macaca_mulatta.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://zipcodezoo.com/ Image, courtesy of David Stang, BayScience Foundation]
}}

Element:MPMV - Revision history

imported>Gydbwiki at 15:16, 3 May 2010