imported>Gydbwiki at 08:44, 4 May 2010

2010-05-04T08:44:19Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=11078528 AF221065]
|type=
Undetermined
|genus=
Gammaretrovirus
|subfamily=
Class 1
|family=
Retroviridae
|group=
LTR retroelements
|description=''Murine Leukemia Virus'' (MuLV), occurring in mice is a C-type retrovirus that can be divided into four classes ([[Literature:30647|Herr 1984]]; [[Literature:72733|Stoye and Coffin 1987]];[[Literature:85425|O' Neill ''et al.'' 1985]]) according to the following host ranges:

*Ecotropic MLVs, which infect mouse cells and are horizontally and vertically transmitted in ''Mus musculus''
*Polytropic MLVs, and modified polytropic MLVs, both usually isolated from leukemogenic tissues and capable of infecting mouse cells, and the cells of other organisms
*Xenotropic MLVs, unable to proliferate in mouse cells by infection but capable of infecting cells of other species

The xenotropic DG-75 MLV is taken as a representative, its genome is 8.2 Kb size including Pro-5´LTR and Pro-3´LTR of 143 and 471 nt, respectively. The internal region of this retrovirus displays two possible tRNA Primer Binding Sites (PBS) identified in genbank accession as Y=T and S=C for a tRNAThr; and Y=C and S=G for a tRNAGlu-2, a single Open Reading Frame (ORF) ''gag-pol'', an ORF for ''env'' gene, and also a Polypurine Tract (PPT) adjacent to the 3´LTR ([[Literature:61879|Raisch ''et al.'' 2003]]).
|structure=Mulv.png
|host=Mus sp.
|hostpic=Mus_sp.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Joaquin Panadero, Copyright, GyDB, Biotech Vana]
}}

Element:MuLV - Revision history

imported>Gydbwiki at 08:44, 4 May 2010