imported>Gydbwiki at 08:29, 4 May 2010

2010-05-04T08:29:51Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=28927668 AF246698]
|type=
Undetermined
|genus=
Gammaretrovirus
|subfamily=
Class 1
|family=
Retroviridae
|group=
LTR retroelements
|description=''Avian Reticuloendotheliosis Virus'' (REV) is a C-type retrovirus originally described in turkeys and chickens and has also been described as an integrated in the ''Fowlpox virus'' genome. REV induces reticuloendotheliosis, a neoplastic disease of the lymphoreticular system in birds ([[Literature:76564|Theilen, Zeigel and Twiehaus 1966]]; [[Literature:85435|Franklin, Maldonado and Bose 1974]]; [[Literature:85436|Hoelzer ''et al.'' 1980]]), and carries an oncogene of 1.4 Kb integrated within the ''env'' gene ([[Literature:85437|Stephens ''et al.'' 1983]]). During the infection the virus generates two species of unintegrated linear DNA genomes of 8.3 and 5.5 Kb, which represent the virus collaborator (REV-A) and the defective oncogenic component (REV-T), respectively ([[Literature:85438|Chen ''et al.'' 1981]]; [[Literature:85439|Wilhelmsen, Eggleton and Temin 1984]]).

The sequence taken as a representative to describe the genomic structure of REV, is 8 Kb in size including LTRs of 511 and 250 nt, respectively. The internal region displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Pro</sup>, Open Reading Frames (ORFs) for ''gag-pol'', and'' env'' genes characteristic of retroviruses, and a Polypurine Tract (PPT) adjacent to the 3´LTR ([[Literature:85434|Hertig ''et al.'' 1997]]; [[Literature:85433|Moore ''et al.'' 2000]]; [[Literature:37997|Kim and Tripathy 2001]]; [[Literature:85395|Singh, Schitzlein and Tripathy 2003]]; [[Literature:85431|Garcia ''et al.'' 2003]]; [[Literature:85432|Tadese and Reed 2003]]).
|structure=Rev.png
|host=Gallus sp.
|hostpic=Gallus_sp.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Enrique Donat, <br>Copyright, GyDB, Biotech Vana]
}}

Element:REV - Revision history

imported>Gydbwiki at 08:29, 4 May 2010