imported>Ldominguez at 08:27, 3 May 2010

2010-05-03T08:27:12Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=221012 D10652]
|type=
Undetermined
|genus=
Alpharetrovirus
|subfamily=
Class 2
|family=
Retroviridae
|group=
LTR retroelements
|description= ''Rous Sarcoma Virus'' (RSV) is an avian oncogenic retrovirus, reported by Peyton Rous in 1911 as an infectious tumor agent inductor ([[Literature:100802|Rous 1910]]). RSV has several variants, the Schmidt-Ruppin D strain has been taken as representative. The genomic structure of this clone is 9.3 Kb in size including pro-5´LTR and pro-3´LTR of 101 and 246 nt, respectively. The internal region displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Trp</sup>, Open Reading Frames (ORFs) for ''gag'', ''pol'', and ''env'' genes characteristic of retroviruses, an oncogen ''src'', and a Polypurine Tract (PPT) adjacent to the 3´LTR ([[Literature:67739|Schwartz, Tizard and Gilbert 1983]]; [[Literature:52124|Morris and Leis 1999]]). The ''src'' oncogen is evolutionarily related with a host-native proto-oncogene displayed in certain avian genomes, and codifies for a Tyrosine Kinase that binds phosphate groups to tyrosine residues in various host cell proteins ([[Literature:72235|Steheling ''et al.'' 1976]]; [[Literature:71526|Spector, Varmus and Bishop 1978]]; [[Literature:85407|Bishop 1985]]).
|structure=Rsv.png
|host=Gallus sp.
|hostpic=Gallus_sp.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Enrique Donat, <br>Copyright, GyDB, Biotech Vana]
}}

Element:RSV - Revision history

imported>Ldominguez at 08:27, 3 May 2010