imported>Gydbwiki at 15:14, 3 May 2010

2010-05-03T15:14:20Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=2246459 U85505]
|type=
Undetermined
|genus=
Betaretrovirus
|subfamily=
Class 2
|family=
Retroviridae
|group=
LTR retroelements
|description= ''Simian Endogenous Retrovirus of Mandrill'' (SERV) is a D-type retrovirus described from a mandrill genomic library ([[Literature:78737|Van der Kuyl ''et al.'' 1997]]). Later PCR analyses also revealed sequences related to SERV in Old World monkeys of the ''Cercopithecinae'' subfamily. This retrovirus belongs to the genus ''Betaretrovirus'', which comprises both B- and D-type retroviruses. Interestingly, D-type betaretroviruses present a common surface receptor also used by the baboon and cat endogenous C-type gammaretroviruses (BaEVM, RD114), cellular infection by any of them can interfere with other D-type members, and also with BaEVM and RD114 ([[Literature:12209|Chatterjee and Hunter 1980]]; [[Literature:71083|Sommerfelt and Weiss 1990]]). This evidence seems to be related with the high similarity displayed between env polyproteins encoded by gammaretroviruses and D-type betaretroviruses, indicating that betaretroviruses and gammaretroviruses may have been involved in an ancient recombinatorial event ([[Literature:71146|Sonigo ''et al.'' 1986]]; [[Literature:100589|Fauquet ''et al''. 2005]]) or that they share a common ancestor ([[Phylogeny:ENV_Retroviridae|see env tree in section "phylogenies"]]).

The genomic structure of SERV is 8.4 Kb size, including LTRs of 346 nt. The internal region displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Lys3</sup>; four Open Reading Frames (ORFs) for ''gag'', ''dut/pro'', ''pol'', and ''env'' genes, and a Polypurine Tract (PPT), as well, adjacent to the 3′LTR ([[Literature:78737|Van der Kuyl ''et al.'' 1997]]; [[Literature:20174|Elder ''et al.'' 1992]]; [[Literature:58348|Payne and Elder 2001]]). We also have found that SERV also presents a putative accessory gene ''Orf-x'' that is common among many other betaretroviruses, and that was originally described in JSRV betaretroviruses ([[Literature:3496|Bai ''et al.'' 1999]]; [[Literature:64403|Rosati ''et al.'' 2000]]).
|structure=Serv.png
|host=Mandrill sp.
|hostpic=Mandrill_sp.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Joaquin Panadero, <br>Copyright, GyDB, Biotech Vana]
}}

Element:SERV - Revision history

imported>Gydbwiki at 15:14, 3 May 2010