imported>Gydbwiki at 08:57, 4 May 2010

2010-05-04T08:57:56Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=61965 X54482]
|type=
Undetermined
|genus=
Spumaretrovirus
|subfamily=
Class 3
|family=
Retroviridae
|group=
LTR retroelements
|description=''Simian Foamy Virus type 1'' (SFV-1) is a foamy retrovirus that belongs to the genus ''Spumaretrovirus'' (for a review see [[Literature:49494|Meiering and Linial 2001]]). SFV-1 has orthologues in other mammals ([[Literature:85497|Flügel 1991]]). Several studies have reported persistent SFV-1 infections in human beings exposed to apes. These zoonosis cases suggest that ape retroviruses can be transmitted to humans more frequently that originally thought ([[Literature:73706|Switzer ''et al.'' 2004]] and references therein). SFV-1, however, does not show ''in vitro'' cytopathology and apparent pathogenic effects have not been reported in infected individuals ([[Literature:49779|Mergia ''et al.'' 1997]]).

The genomic structure of SFV-1 is 13 Kb in size including LTRs of 1.6 Kb. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Lys1-2</sup>, Open Reading Frames (ORFs) for ''gag'', ''pol'' and'' env '' genes characteristic of retroviruses, accessory genes ''bel1'' and ''bel2'', and a Polypurine Tract (PPT) adjacent to the 3´LTR ([[Literature:40643|Kupiec ''et al.'' 1991]]; [[Literature:85497|Flügel 1991]]). As described by [[Literature:52900|Muranyi and Flügel]] (1991) in human ''Spumaretrovirus'', a chimeric protein termed Bet (or ''bel3'') has also been observed in SFV-1; it derives from splicing of the N-terminal amino acids of ''bel1'' in frame with the bulk of the ''bel2''.
|structure=SFV-1_final.png
|host=Primates sp.
|hostpic=Primates_sp.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Joaquin Panadero, <br>Copyright, GyDB, Biotech Vana]
}}

Element:SFV-1 - Revision history

imported>Gydbwiki at 08:57, 4 May 2010