imported>Gydbwiki at 07:55, 4 May 2010

2010-05-04T07:55:09Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=61730 Y00277]
|type=
Primate lentiviruses
|genus=
Lentivirus
|subfamily=
Class 2
|family=
Retroviridae
|group=
LTR retroelements
|description= ''Simian Immunodeficiency Retrovirus of Macaques'' (SIVMAC) is a lentivirus closely related to HIV-2 in both genomic structure and sequence. SIVMAC has cytophatic effects and tropism towards CD-4 lymphocytes, and induces acquired Immunodeficiency Syndrome -AIDS- ([[Literature:11770|Chakrabarti ''et al.'' 1987]]). The genomic structure of SIVMAC is 9.6 Kb in size including LTRs of 1 Kb (pro-5´LTR R/U5 and pro-3´LTR 3′ U3/R of 318 nt and 689 nt, respectively. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Lys3</sup>; Open Reading Frames (ORFs) for ''gag'', ''pol'' and ''env'' genes characteristic of retroviruses, ''tat'' and '' rev ''(both expanded in two exons) and ''vif '' (''orf-q''), which are three accessory genes common in other lentiviruses, ''vpx'' (''orf-x''), ''vpr'' (''orf-r''), and ''nef'' (ORF-F) accessory genes specifical of primate lentiviruses, and a Polypurine Tract (PPT) adjacent to the 3'-LTR ([[Literature:11770|Chakrabarti ''et al.'' 1987]]).
|structure=Sivmac.png
|host=Macaca mulatta
|hostpic=Macaca_mulatta.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://zipcodezoo.com/ Image, courtesy of David Stang, BayScience Foundation]
}}

Element:SIVMAC - Revision history

imported>Gydbwiki at 07:55, 4 May 2010