imported>Gydbwiki at 15:17, 3 May 2010

2010-05-03T15:17:35Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=332626 M23385]
|type=
Undetermined
|genus=
Betaretrovirus
|subfamily=
Class 2
|family=
Retroviridae
|group=
LTR retroelements
|description= ''Squirrel Monkey-like Retrovirus'' that occurs in humans (SMRV-H) is a D-type retrovirus characterized from human B lymphocytes ([[Literature:85396|Oda ''et al.'' 1988]]). As this retrovirus is similar to SMRV-like retroviruses, it was named SMRVHLB (abbreviated as SMRV-H). This retrovirus belongs to the genus ''Betaretrovirus'', which comprises of both B- and D-type retroviruses. Interestingly, D-type betaretroviruses present a common surface receptor also used by the baboon and cat endogenous C-type gammaretroviruses (BaEVM, RD114), cellular infection by any of them can interfere with other D-type members, and also with BaEVM and RD114 ([[Literature:12209|Chatterjee and Hunter 1980]]; [[Literature:71083|Sommerfelt and Weiss 1990]]). This evidence seems to be related with the high similarity displayed between env polyproteins encoded by gammaretroviruses and D-type betaretroviruses, indicating that betaretroviruses and gammaretroviruses may have been involved in an ancient recombinatorial event ([[Literature:71146|Sonigo ''et al.'' 1986]]; [[Literature:100589|Fauquet ''et al''. 2005]]) or that they share a common ancestor ([[Phylogeny:ENV_Retroviridae|see env tree in section "phylogenies"]]).

The genomic structure of SMRV-H is 8.8 Kb size including LTRs of 456 nt. The internal region displays a Primer Binding Site (PBS) complementary to a tRNALys1,2, Open Reading Frames (ORFs) for ''gag'', ''dut/protease'', ''pol'', and ''env'' genes, and a Polypurine Tract (PPT), adjacent to the 3´LTR ([[Literature:85396|Oda ''et al.'' 1988]]; [[Literature:20174|Elder ''et al.'' 1992]]; [[Literature:58348|Payne and Elder 2001]]). We also have found that SMRV-H also presents a putative accessory gene Orf-x that is common among many other betaretroviruses, and that was originally described in JSRV betaretroviruses ([[Literature:3496|Bai ''et al.'' 1999]]; [[Literature:64403|Rosati ''et al.'' 2000]]).
|structure=Smrv-h.png
|host=Homo sapiens
|hostpic=Homo_sapiens.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Carlos Llorens, Copyright, GyDB, Biotech Vana]
}}

Element:SMRV-H - Revision history

imported>Gydbwiki at 15:17, 3 May 2010