imported>Gydbwiki at 15:16, 3 May 2010

2010-05-03T15:16:55Z

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=334746 M11841]
|type=
Undetermined
|genus=
Betaretrovirus
|subfamily=
Class 2
|family=
Retroviridae
|group=
LTR retroelements
|description= ''Simian Retrovirus type 1'' (SRV-1) is a D-type retrovirus, characterized as the possible causal agent of the Immunodeficiency syndrome in macaques ([[Literature:85397|Power ''et al.'' 1986]]). This retrovirus belongs to the genus ''Betaretrovirus'', which is comprised of both B- and D-type retroviruses. In this regard, D-type betaretroviruses present a common surface receptor also utilized by the baboon and cat endogenous C-type gammaretroviruses (BaEVM, RD114). Cellular infection by any of them can interfere with other D-type members, and also with BaEVM and RD114 ([[Literature:12209|Chatterjee and Hunter 1980]]; [[Literature:71083|Sommerfelt and Weiss 1990]]). This evidence seems to be related with the high similarity displayed between env polyproteins encoded by gammaretroviruses and D-type betaretroviruses, indicating that betaretroviruses and gammaretroviruses may have been involved in an ancient recombinatorial event ([[Literature:71146|Sonigo ''et al.'' 1986]]; [[Literature:100589|Fauquet ''et al''. 2005]]) or that they share a common ancestor ([[Phylogeny:ENV_Retroviridae|see env tree in section "phylogenies"]]).

At the genome structure level SRV-1 is 8.2 Kb size including LTRs of 346 nt. The internal region of this retrovirus displays a primer binding site (PBS) complementary to a tRNA<sup>Lys</sup>; Open Reading Frames (ORFs) for ''gag'', ''dut/pr'', ''pol'', and ''env'' genes and a Polypurine Tract (PPT), adjacent to the 3´LTR. Both LTRs of SRV-1 display a small ORF called ''sorf'' ([[Literature:85397|Power ''et al.'' 1986]]; [[Literature:20174|Elder ''et al.'' 1992]]; [[Literature:58348|Payne and Elder 2001]]), which is also displayed in MPMV as a three-domain ORF. We also have found that SRV-1 also presents a putative accessory gene ''Orf-x'' that is common among many other betaretroviruses, and that was originally described in JSRV betaretroviruses ([[Literature:3496|Bai ''et al.'' 1999]]; [[Literature:64403|Rosati ''et al.'' 2000]]).
|structure=Srv-1.png
|host=Macaca mulatta
|hostpic=Macaca_mulatta.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://zipcodezoo.com/ Image, courtesy of David Stang, BayScience Foundation]
}}

Element:SRV-1 - Revision history

imported>Gydbwiki at 15:16, 3 May 2010