imported>Gydbwiki at 14:02, 28 January 2010

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{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=173084 M34549]
|type=
Ty3
|genus=
Undetermined
|subfamily=
Chromoviruses
|family=
Ty3/Gypsy
|group=
LTR retroelements
|description=''Ty3'' is a LTR retrotransposon with specificity for integrating next to tRNA genes in ''Saccharomyces cerevisiae'' ([[Literature:13594|Clark et al. 1988]]; [[Literature:29144|Hansen, Chalker, and Sandmeyer 1988]]; [[Literature:29143|Hansen and Sandmeyer 1990]]). ''Ty3'' does not bear a detectable chromodomain at the integrase domain, but is phylogenetically related to the ''Chromoviridae'' branch ([[Literature:47259|Marín and Lloréns 2000]]), term suggested ([[Literature:47259|Marín and Lloréns 2000]]) to describe the ''Ty3/Gypsy'' elements bearing chromodomain-integrases ([[Literature:46552|Malik and Eickbush 1999]]). The chromovirus branch has been disclosed to be the most ancient phylogenetic pattern of ''Ty3/Gypsy'' retroelements ([[Literature:26737|Gorinsek, Gubensek and Kordis 2004]]; [[Literature:26736| 2005]]; [[Literature:39523|Kordis 2005]]).

''Ty3'' has at least two subtypes ''Ty3-1'' and ''Ty3-2'' ([[Literature:29144|Hansen, Chalker, and Sandmeyer 1988]]). ''Ty3-1'' has been taken as representative. ''Ty3''-1 occurs, 16 bp upstream of the 5' end of a tRNA<sup>Cys</sup> gene, and its genomic structure is 5.5 Kb in size, including LTRs of 339 nt. The internal region of this element displays a Primer Binding Site (PBS), two Open Reading Frames (ORFs) for ''gag'', and ''pol'' genes, and a Polypurine Tract (PPT) adjacent to the 3´LTR. The ''gag'' gene only encodes two major structural proteins, capsid (CA) and nucleocapsid (NC) ([[Literature:85447|Hansen et al. 1992]]). ''Ty3'' differs from other fungi and vertebrate chromoviruses in that it displays, like plant chromoviruses, a primer binding site (PBS) complementary to a tRNAi-Met. Note that the PBS of fungi and vertebrate chromoviruses, differs significantly from that used by plant chromoviruses. While plant chromoviruses use a methionine starting tRNA (iMet), fungi and vertebrate chromoviruses use their own self-priming mechanism to start the reverse transcription ([[Literature:43217|Levin 1995 ]]; [[Literature:10125|Butler et al. 2001]]).
|structure=Ty3-1.png
|host=Saccharomyces cerevisiae
|hostpic=Saccharomyces_cerevisiae.gif
|literature=*[[Literature:15303|Mobile DNA II. (Craig et al. 2002)]]
|picowner=[http://www.biotechvana.com Image, Joaquin Panadero, <br>Copyright, GyDB, Biotech Vana]
}}

Element:Ty3-1 - Revision history

imported>Gydbwiki at 14:02, 28 January 2010