imported>Gydbwiki at 15:40, 3 May 2010

2010-05-03T15:40:45Z

New page

{{Element
|genbank=[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=470313 M10608]
|type=
Ovine/Caprine lentiviruses
|genus=
Lentivirus
|subfamily=
Class 2
|family=
Retroviridae
|group=
LTR retroelements
|description=''Maedi Visna Virus'' (VMV) is a lentivirus with antigenic variation and described in sheep and goat genomes ([[Literature:71147|Sonigo ''et al.'' 1985]]; [[Literature:8577|Braun, Clements and Gonda 1987]]; [[Literature:13778|Clements ''et al.'' 1988]]). The genomic structure of a typical VMV retrovirus is 9.2 Kb including LTRs of 510 nt (pro 5´LTR-R/U5 and pro 3´LTR-U3/R of 160 and 350 nt, respectively). The internal region displays a Primer Binding Site (PBS) complementary to a tRNA<sup>Lys</sup>, Open Reading Frames (ORFs) for ''gag'', ''pol'' and ''env'' genes characteristic of retroviruses, ''tat'' and ''rev'' and ''orfq'' (''vif ''or ''sor''), which are three accessory genes common in other lentiviruses, an ''orfw'' also displayed but corrupted in other sheep lentiviruses, and adjacent to the 3´LTR, a Polypurine Tract (PPT) common to other LTR retroelements ([[Literature:71147|Sonigo ''et al.'' 1985]]). As other non-primate lentiviruses, VMV displays between the RNase H and INT domains, an ORF coding for a dUTPase (dU) similar to that observed in betaretroviruses, N-terminal to the PR domain ([[Literature:20174|Elder ''et al.'' 1992]]; [[Literature:58348|Payne and Elder 2001]] and references therein).
|structure=Vmv.png
|host=Ovis sp.
|hostpic=Ovis_sp.gif
|literature=
*[[Literature:14014|Retroviruses. (Coffin, Hugges and Varmus 1997)]]
|picowner=[http://www.biotechvana.com Image, Enrique Donat, <br>Copyright, GyDB, Biotech Vana]
}}

Element:VMV - Revision history

imported>Gydbwiki at 15:40, 3 May 2010