imported>GPbernet at 10:29, 6 May 2011

2011-05-06T10:29:39Z

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''FOB1'' is a host gene found in certain fungal organisms whose protein encoded product is an integrase (INT) like enzyme of 510-535 residues that is involved in the rDNA metabolism ([[literature:100808|Dlakic 2002]]). For simplicity´s sake the figure below shows the genomic structure without introns.

<center>[[File:FOB1.jpg]]</center>

There are two complementary classifications for ''FOB1''. Based on sequence this gene can be classified as a member of the pool of DDE transposases (TRs) and (INTs). Within this scenario, phylogenetic inference suggests that ''FOB1'' is related to the ''GINGER2'' transposons ([[literature:100807|Bao ''et al''. 2010]]) and the ''SCAN/KRAB'' genes (which are domesticated ''GINGER2'' transposons). On the other hand, in 2002 ''FOB1'' a protein involved in the rDNA metabolism of ''Saccharomyces'' was related to retroviral INTs ([[literature:100808|Dlakic 2002]]). Based on INT-like structural potential similarities, the INT coded by ''FOB1'' is member of the Retroviral Integrase Superfamily ([[literature:100803|Nowotny 2009]]) of nucleic acid-processing enzymes involved in; a) selfish evolution; b) replication and repair of DNA; c) recombination and gene fusion; d) RNA-mediated gene silencing; and e) oncogenesis.

FOB1 - Revision history

imported>GPbernet at 10:29, 6 May 2011