imported>GPbernet at 17:32, 27 May 2011

2011-05-27T17:32:33Z

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The Gypsy-like-Integrase Type 2 (''GIN-2'') ([[literature:100807|Bao ''et al''. 2010]]; [[literature:100812|Marin 2010]]) is an intron-exon host integrase (INT) gene of 1.2-3.4 kb, exclusively found in the genomes of vertebrates. The name of ''GIN-2'' logically derives from the previous description of a counterpart of ''GIN-2'' called ''GIN-1''. These two genes are not true paralogs but host genes evolved from the pool of ''GINGER1'' elements, which in turn are related to LTR retroelement INTs. The ''GIN-2'' product shows the typical INT core but it apparently lacks the GPY/F module typically observed in the phyologenetic relatives of GIN2 (such as the GIN1 protein, the LTR retroelement INTs and the ''GINGER1'' transposons). For simplicity´s sake the figure below shows the genomic structure without introns.

<center>[[File:Gin2n.jpg]]</center>

There are two complementary classifications for the ''GINGER1'' elements. Based on sequence these elements can be classified as DDE TRs and INTs. Based on INT-like structural potential similarities, the INT coded by ''GINGER1'' elements are members of the Retroviral Integrase Superfamily ([[literature:100803|Nowotny 2009]]) of nucleic acid-processing enzymes involved in; a) selfish evolution; b) replication and repair of DNA; c) recombination and gene fusion; d) RNA-mediated gene silencing; and e) oncogenesis.

GIN-2 - Revision history

imported>GPbernet at 17:32, 27 May 2011