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''GINNY'' is a recently described pool of exon-intron transposons ([[literature:100812|Marin 2010]]) which encode for a transposase (TR) showing the occurrence of a GPY/F module ([[literature:4655|Malik & Eickbush 1999]]) thought to mediate multimerization ([[literature:88856|Ebina ''et al''. 2008]]) at its C-terminus. ''GINNY'' elements show an additional module adjacent to the GPY/F module, which depending on the element may be an ovarian tumor ([http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=190283 OTU]) cysteine protease domain, or an [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=145846 Ulp1] protease catalytic domain ([[literature:100812|Marin 2010]]). The latter may also be coupled with a plant homeodomain ([http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=197604 PHD]) finger motif. According to [[literature:100812|Marin 2010]], full-length ''GINNY'' elements are approximately 3.5 Kb, and flanked by terminal inverted repeats (TIRs) of approximately 111 nucleotides long (Figure not to scale). For simplicity´s sake the figure below shows the genomic structure without introns.
<center>[[File:Ginny.png]]</center>
''GINNY'' elements belong to the phylogenetic cluster of TRs and integrases (INTs) constituted by the ''GINGER1''-like transposons ([[literature:100807|Bao ''et al''. 2010]]) (which give the name to the cluster), the two ''GIN''-like host genes of vertebrates ([[literature:44593|Llorens & Marin 2001]]; [[literature:100807|Bao ''et al''. 2010]]; [[literature:100812|Marin 2010]]), and other transposons called ''GINO'' and ''GINA'' ([[literature:100812|Marin 2010]]). There are two complementary classifications for the ''GINGER1'' elements. Based on sequence, these elements can be classified as DDE TRs and INTs. Based on INT-like structural potential similarities, the INT coded by ''GINGER1'' elements are members of the Retroviral Integrase Superfamily ([[literature:100803|Nowotny 2009]]) of nucleic acid-processing enzymes involved in: a) selfish evolution; b) replication and repair of DNA; c) recombination and gene fusion; d) RNA-mediated gene silencing; and e) oncogenesis.

GINNY - Revision history

imported>GydbAdmin at 12:05, 4 November 2011