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The Chromatin Organization Modifier Domain (chromodomain) is a protein domain of approximately 50 residues in length, originally identified as a motif common to the ''Drosophila'' chromatin proteins Polycomb (Pc) and the heterochromatin protein1 HP1. [[chromo_all|Chromodomains]] are involved in chromatin remodeling and regulation of the gene expression in eukaryotes ([[Literature:39429|Koonin, Zhou and Lucchesi 1995]]; [[Literature:11540|Cavalli and Paro 1998]]). Almost but not all elements belonging to a lineage of ''Metaviridae Ty3/Gypsy'' LTR retrotransposons described in the genomes of plants, fungi, and vertebrates, are carriers of a chromodomain displayed at the C-terminal end of their integrases ([[Literature:46552|Malik and Eickbush 1999]]). In light of this evidence, the term "''Chromoviridae''" was suggested to describe this lineage as a genus ([[Literature:47259|Marin and Lloréns 2000]]) whose diversity has been found to be greater than previously thought ([[Literature:26737|Gorinsek, Gubensek and Kordis 2004]]; [[Literature:26736| 2005]]). The origin of chromoviruses has been significantly extended by the finding of representatives in the most basal plant lineages, those of green and red algae ([[Literature:26737|Gorinsek, Gubensek and Kordis 2004]]; [[Literature:26736| 2005]]), revealing that within ''Ty3/Gypsy'' elements, chromoviruses represent the so far oldest and most widespread lineage (See also [[Literature:39523|Kordis 2005]]).

[[Image:ty3gypsy_chromo_1.gif|center]]

[[Category:Retroelements]]

LTR retroelement chromodomains - Revision history

imported>Gydbwiki at 15:35, 17 September 2009