imported>Gydbwiki at 14:13, 15 July 2011

2011-07-15T14:13:41Z

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''Tdd-4'' and ''Tdd-5'' are two intron-exon structured cut and paste DNA transposons described in the genome of ''Dictyostelium discoideum'' ([[literature:82318|Wells 1999]]; [[literature:26055|Glockner ''et al''. 2001]]). Full-length ''Tdd-4'' and ''Tdd-5'' elements are 3.7 and 3.8 kb respectively, and are flanked by terminal inverted repeats (TIRs) of 260 and 297 nucleotides long (Figure not to scale). For simplicity´s sake the figure below shows the genomic structure without introns.

<center>[[File:Tdd.jpg]]</center>

There are two complementary classifications for the ''Tdd''-like transposons. Based on sequence these elements can be classified as DDE TRs and integrases (INTs). Within this scenario, phylogenetic inference suggests that ''Tdd''-like elements are related to the ''GINGER2'' transposons ([[literature:100807|Bao ''et al''. 2010]]) but also to the ''FOB1'' genes and the ''SCAN/KRAB'' genes (which are domesticated ''GINGER2'' transposons). Based on INT-like structural potential similarities, the INT coded by ''Tdd''-like transposons are members of the Retroviral Integrase Superfamily ([[literature:100803|Nowotny 2009]]) of nucleic acid-processing enzymes involved in; a) selfish evolution; b) replication and repair of DNA; c) recombination and gene fusion; d) RNA-mediated gene silencing; and e) oncogenesis.

TDD - Revision history

imported>Gydbwiki at 14:13, 15 July 2011