Atlantic salmon swim bladder sarcoma virus (ASSBSV) is an epsilonretrovirus originally isolated from Salmo salar species. ASSBSV belongs to genus Epsilonretrovirus within Retroviridae family (International Committee on the Taxonomy of Viruses -ICTV- Fauquet et al. 2005) and according to Llorens et al. 2009 is located within Class 1 of the Retroviridae family. This retrovirus-infected salmons usually are in poor physical condition and display swollen abdomens that upon necropsy were found to contain multinodular masses of neoplastic cells occupying external and internal surfaces of the swim bladder. These tumors, histologically classified as leiomyosarcomas or fibrosarcomas (McKnight 1978), cause an approximately a 35% of population mortality (Paul et al. 2006).

The genomic structure of ASSBSV is 10.9 Kb in length, including LTRs of 713 pb of sequence at each end of the proviral genome (Paul et al. 2006). The internal region of this retrovirus displays a Primer Binding Site (PBS), three Open Reading Frames (ORFs) for gag, pol (PR, RT, RNaseH, INT) and env genes characteristic of retroviruses, as well as a Polypurine Tract (PPT) adjacent to the 3´LTR (Paul et al. 2006).


ASSBSV final.png

Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession: 76786461
Clade: Undetermined
Cluster or genus: Epsilonretrovirus
Branch or class: Class 1
Family: Retroviridae
System: LTR retroelements
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Salmo salar
Courtesy of Duane Raver/USFWS
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Welcome to the Gypsy Database (GyDB) an open editable database about the evolutionary relationship of viruses, mobile genetic elements (MGEs) and the genomic repeats where we invite all authors to contribute with their knowledge to improve and expand the topics.
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Llorens, C., Futami, R., Covelli, L., Dominguez-Escriba, L., Viu, J.M., Tamarit, D., Aguilar-Rodriguez, J. Vicente-Ripolles, M., Fuster, G., Bernet, G.P., Maumus, F., Munoz-Pomer, A., Sempere, J.M., LaTorre, A., Moya, A. (2011) The Gypsy Database (GyDB) of Mobile Genetic Elements: Release 2.0 Nucleic Acids Research (NARESE) 39 (suppl 1): D70-D74 doi: 10.1093/nar/gkq1061

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