Gibbon Ape Leukemia Virus (GaLV) is a C-type oncogenic virus that induces myeloid leukemia in young gibbons. GaLV infects an especially large variety of cellular types in various species (Johann, Gibbons and O’Hara 1992; Hunter 1997). This evidence has been useful in developing genetic transference viral vectors in vivo and ex vivo (Miller et al. 1991; Wilson et al. 1989). The genomic structure of GaLV is 8.1 Kb size including pro-5´LTR and pro-3´LTR of 125 and 437 nt, respectively. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNAPro, Open Reading Frames (ORFs) for gag-pol and env genes characteristic of retroviruses, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Delassus, Sonigo and Wain-Hobson 1989).
Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:
|DU or DUT=dUTPase
|TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
|PBS=primer binding site
|ATF=aphid transmission factor
|VAP=virion associated protein