Mus dunni Endogenous Retrovirus (MdEV) is a murine retrovirus originally isolated in Mus dunni wild mouse during experiments with human cells in order to obtain competent virus replicates in human transference experiments (Miller et al. 1996). MdEV is activated in response to 5-iode-2*deoxiuridine or hydrocortisone treatment. Various interference analyses have reported that MdEV, as opposed to other murine retroviruses, uses six different receptors to penetrate its host (Miller and Wolgamot 1997; Bonham, Wolgamot, and Miller 1997). The genomic structure of MdEV is 8.6 Kb in size including pro-LTRs 5′ and 3′ of 179 and 770 nt respectively. The internal region displays a Primer Binding Site (PBS) complementary to a tRNAGly, Open Reading Frames (ORFs) for gag-pol and env genes characteristic of retroviruses, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Wolgamot, Bonham and Miller 1998).
Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:
|DU or DUT=dUTPase
|TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
|PBS=primer binding site
|ATF=aphid transmission factor
|VAP=virion associated protein