Simian Immunodeficiency Retrovirus (SIVAGM) is a complex retrovirus described in African green monkeys and phylogenetically related to HIV-1 and other lentiviruses inductor of Acquired Immunodeficiency Syndrome (AIDS) in primates (Daniel et al. 1988; Muller et al. 1993). The genomic structure of SIVAGM is 9.8 Kb in size including LTRs of 715-710 nt. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNALys3, Open Reading Frames (ORFs) for gag, pol and env genes characteristic of retroviruses, tat and rev (both expanded in two exons) and vif, which are three accessory genes common in other lentiviruses, vpx and nef accessory genes specifically observed in primate lentiviruses, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Soares et al. 1997).
Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:
|DU or DUT=dUTPase
|TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
|PBS=primer binding site
|ATF=aphid transmission factor
|VAP=virion associated protein