Tdd-4 and Tdd-5 are two intron-exon structured cut and paste DNA transposons described in the genome of Dictyostelium discoideum (Wells 1999; Glockner et al. 2001). Full-length Tdd-4 and Tdd-5 elements are 3.7 and 3.8 kb respectively, and are flanked by terminal inverted repeats (TIRs) of 260 and 297 nucleotides long (Figure not to scale). For simplicity´s sake the figure below shows the genomic structure without introns.


There are two complementary classifications for the Tdd-like transposons. Based on sequence these elements can be classified as DDE TRs and integrases (INTs). Within this scenario, phylogenetic inference suggests that Tdd-like elements are related to the GINGER2 transposons (Bao et al. 2010) but also to the FOB1 genes and the SCAN/KRAB genes (which are domesticated GINGER2 transposons). Based on INT-like structural potential similarities, the INT coded by Tdd-like transposons are members of the Retroviral Integrase Superfamily (Nowotny 2009) of nucleic acid-processing enzymes involved in; a) selfish evolution; b) replication and repair of DNA; c) recombination and gene fusion; d) RNA-mediated gene silencing; and e) oncogenesis.

Welcome to the Gypsy Database (GyDB) an open editable database about the evolutionary relationship of viruses, mobile genetic elements (MGEs) and the genomic repeats where we invite all authors to contribute with their knowledge to improve and expand the topics.
Cite this project:

Llorens, C., Futami, R., Covelli, L., Dominguez-Escriba, L., Viu, J.M., Tamarit, D., Aguilar-Rodriguez, J. Vicente-Ripolles, M., Fuster, G., Bernet, G.P., Maumus, F., Munoz-Pomer, A., Sempere, J.M., LaTorre, A., Moya, A. (2011) The Gypsy Database (GyDB) of Mobile Genetic Elements: Release 2.0 Nucleic Acids Research (NARESE) 39 (suppl 1): D70-D74 doi: 10.1093/nar/gkq1061

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